Page last updated: 2024-08-23

pravastatin and (3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

pravastatin has been researched along with (3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid in 239 studies

Research

Studies (239)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's47 (19.67)18.2507
2000's149 (62.34)29.6817
2010's35 (14.64)24.3611
2020's8 (3.35)2.80

Authors

AuthorsStudies
Ferguson, E; Krause, BR; Newton, RS; Roth, BD; Shaw, MK; Sliskovic, DR1
Garnett, WR2
Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR1
Arpaia, G; Bonfardeci, G; Cimminiello, C; Lorena, M; Merlo, B; Milani, M1
Benghozi, R; Holmes, D; Jacotot, B; Pfister, P1
Hoshi, K; Ichihara, K; Itoh, S; Yamamoto, A2
Carmena, R1
Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR1
Donetti, E; Ferrari, C; Fumagalli, R; Mazzini, G; Paoletti, R; Parolini, C; Soma, MR1
Gotto, AM; Hay, JW1
Lopez, D; Ness, GC; Zhao, Z1
Arnaboldi, L; Corsini, A; Fumagalli, R; Paoletti, R; Quarato, P; Raiteri, M1
Feingold, KR; Marcelino, JJ1
Chilton, R1
Pedersen, TR; Tobert, JA1
Dayer, P; Leemann, T; Transon, C1
Hughes, AD1
Donetti, E; Fumagalli, R; Paoletti, R; Parolini, C; Soma, MR1
Masters, P; Shetty, A1
Arpaia, G; Bonfardeci, G; Cimminiello, C; Lorena, M; Milani, M; Soncini, M1
Bandoh, T; Hayashi, S; Ishikawa, J; Kimura, M; Kusumi, Y; Mitani, H; Niihashi, M; Sakurai, I; Totsuka, T2
Hayashi, S; Niwa, S; Totsuka, T1
Desager, JP; Horsmans, Y1
Fager, G; Lennernäs, H1
Roberts, WC1
Scheen, AJ1
Granger, DN; Kimura, M; Kurose, I; Russell, J1
Baetta, R; Calore, M; Comparato, C; Donetti, E; Fumagalli, R; Paoletti, R; Rossi, A; Soma, MR; Teruzzi, C1
Hunninghake, D; Jones, P; Kafonek, S; Laurora, I1
Arnaboldi, L; Corsini, A; Fumagalli, R; Paoletti, R; Pazzucconi, F; Pfister, P; Sirtori, CR1
Pincus, J1
Anand, R; Burrows, L; Genyk, Y; Knight, R; Moran, V; Schwartz, B1
Ballantyne, CM; Jacobson, TA; Schein, JR; Williamson, A1
Hoshi, K; Ichihara, K; Yamamoto, A2
Bando, T; Masuda, N; Morikawa, H; Nakashima, A; Ohtawa, M1
Elliott, J; Ellis, C; McHaffie, D; Wilkins, G1
O'Grady, J; Schmid, P; Sinzinger, H1
Thomas, M1
Frane, AM; Gantner, SE; Joyce, DM; Kersten, ME; Murdock, AK; Murdock, DK; Murdock, RW; Olson, KJ1
Clare, G; Mann, S1
Asenjo-Barrón, JC; Cárdenas-Vázquez, R; Díaz-Zagoya, JC; Juárez-Oropeza, MA; Martínez, F1
Branchi, A; Fiorenza, AM; Macor, S; Muzio, F; Rovellini, A; Sommariva, D; Torri, A1
Farnier, M1
Hoshi, K; Ichihara, K; Satoh, K; Yamamoto, A1
Stalenhoef, AF; Stehouwer, CD1
Chan, M; Giannetti, N; Hayashi, S; Hunt, SA; Kato, T; Kobayashi, T; Morimoto, S; Namii, Y; Tokoro, T; Yokoyama, I1
Bellosta, S; Bernini, F; Corsini, A; Ferri, N; Paoletti, R1
Cobos, A; García-Altés, A; García-Closas, R; Jovell, AJ; Serra-Majem, L1
Backman, JT; Kantola, T; Kivistö, KT; Neuvonen, PJ; Niemi, M1
Dansette, PM; Jaoen, M; Pons, C1
Chien, KC; Inoue, M; Kasahara, E; Ohnishi, Y; Suzumura, K1
Ikeda, U; Inaba, H; Ohki, R; Shimada, K; Shimpo, M; Takahashi, M; Yamamoto, K1
Cromwell, WC; Ziajka, PE1
Ose, L; Risberg, K; Svilaas, A; Thoresen, M1
García-Altés, A; Jovell, AJ1
Davidson, MH1
Stein, EA2
Aikawa, M; Enomoto, M; Fukumoto, Y; Hill, CC; Hirouchi, Y; Libby, P; Rabkin, E; Shiomi, M1
Kersting, F; Selenka, A; Walch, S1
Iwasaki, K; Masuda, N; Morikawa, H; Nakashima, A; Ohtawa, M1
Crouch, MA1
Aoki, T; Hasegawa, G; Hori, M; Imaeda, A; Kondo, M; Kondo, Y; Nakamura, N; Nishino, H; Obayashi, H; Ogata, M; Tokuda, K; Yoshikawa, T1
Rosenson, RS; Schaefer, EJ; Tangney, CC1
Fujita, H; Fujita, T; Fukumoto, S; Nakano, T; Takeuchi, Y; Watanabe, S1
Ando, A; Hori, M; Horio, M; Imai, E; Kawada, N; Moriyama, T; Nagatoya, K; Takeji, M1
Lupattelli, G; Palumbo, B; Sinzinger, H1
Maeda, K; Minami, M; Yasunari, K; Yoshikawa, J1
Maclaine, GD; Patel, H1
Enomoto, M; Hirouchi, Y; Ito, T; Shiomi, M2
Andrews, TC; Ballantyne, CM; Hsia, JA; Kramer, JH1
Iwasaki, K; Kuroda, N; Nakashima, A; Nakashima, K; Ohtawa, M; Wada, M1
Auer, J; Eber, B1
Berryman, ER; Gregory, CR; Griffey, SM; Katznelson, S; Kyles, AE1
Igel, M; Sudhop, T; von Bergmann, K1
Griffin, BP; Lauer, MS; Novaro, GM; Pearce, GL; Sprecher, DL; Tiong, IY1
Bazalo, GR1
Chen, H; Liu, R; Xing, Y1
Altamura, L; Chiariello, L; Crea, F; Gaspardone, A; Gioffrè, PA; Proietti, I; Tomai, F; Versaci, F1
Fujita, T; Izumo, N; Koida, M; Nakamuta, H1
Ikeda, U; Kobayashi, E; Ogata, Y; Okazaki, H; Shimada, K; Takahashi, M; Takeuchi, K1
Aaronson, KD; Baliga, RR; Cody, RJ; Dyke, DB; Koelling, TM; Lake, KD; Pagani, FD; Patel, DN1
Hayashi, M; Inoue, T; Morooka, S; Takayanagi, K1
Burgess, DS; Nash, JD; Talbert, RL1
Andersen, M; Gaist, D; García Rodríguez, LA; Hallas, J; Jeppesen, U; Sindrup, SH1
Auteri, A; Bova, G; Bruni, F; Cercignani, M; Console, E; Palazzuoli, A; Pasqui, AL; Puccetti, L1
Ikeda, U; Ito, T; Ohki, R; Shimada, K; Shimpo, M; Takahashi, M; Yamamoto, K1
Asztalos, BF; Horvath, KV; McNamara, JR; Roheim, PS; Rubinstein, JJ; Schaefer, EJ1
Ikeda, U; Ito, T; Shimada, K; Yamamoto, K1
Bonnet, E; Breton, Y; Forestier, F; Janvier, G1
Aoki, T; Imaeda, A; Kaneko, T; Kondo, Y; Nagase, H; Nakamura, N; Yoshikawa, T1
Császár, A; Márk, L1
Ikeda, U; Kobayashi, E; Mano, H; Ogata, Y; Ookawara, S; Shimada, K; Takahashi, M; Takeuchi, K; Ueno, S1
Angori, P; Auteri, A; Bova, G; Bruni, F; Cercignani, M; Palazzuoli, A; Pasqui, AL; Pastorelli, M; Puccetti, L1
Bortolini, EB; Brüch, RS; Buffé, F; Mastalir, ET; Moriguchi, EH; Portal, VL; Rodrigues, R; Schio, S; Vieira, J1
Barouki, R; Gouédard, C; Koum-Besson, N; Morel, Y1
Fuller, S; Gillen, D; Lacey, L; Marriott, J; Wilson, K1
McBurney, CR; Smith, DG1
Begg, E; Gardiner, S; Nicholls, G; Scott, R; Sidwell, A1
Clark, LT1
Fukutomi, T; Imaeda, K; Itoh, M; Okayama, N; Okouchi, M; Omi, H; Shimizu, M1
Oguogho, A; Sinzinger, H1
Brandle, M; Davidson, MB; Herman, WH; Lorber, B; Schriger, DL1
Bandoh, T; Hoshi, K; Inoue, M; Mitani, H; Nakashima, A; Sato, EF1
Betz, W; Devroey, D; Duquet, W; Velkeniers, B1
de Moerloose, P; Dimitrova, Y; Dunoyer-Geindre, S; Kruithof, EK; Mach, F; Reber, G1
Bełtowski, J; Jamroz, A; Wójcicka, G1
Daly, JA; Ferrari, A; Gleason, JL; McNamara, JR; Rubenstein, JJ; Schaefer, EJ; Seman, LJ; Tayler, T1
Edwards, JE; Moore, RA1
Mach, F1
Bonazzi, A; Del Soldato, P; Govoni, M; Guzzetta, M; Ignarro, LJ; Impagnatiello, F; Monopoli, A; Ongini, E1
Bell, PR; Loftus, IM; Molloy, KJ; Naylor, AR; Schwalbe, EC; Thompson, MM1
Benesic, A; Klinker, H; Kluge, F; Langmann, P; Weissbrich, B; Winzer, R; Zilly, M1
Brouwers, AH; de Graaf, L; Diemont, WL1
Hayashi, M; Ichihara, A; Kaneshiro, Y; Koura, Y; Saruta, T; Tada, Y1
Chen, TH; Chen, WM; Chou, SH; Ko, YC; Kuo, TK; Lee, OK; Li, HJ; Su, Y1
Iwagaki, H; Mori, S; Nishibori, M; Takahashi, HK; Tanaka, N; Weitz-Schmidt, G; Yoshino, T1
Inami, S; Mizuno, K; Okamatsu, K; Sakai, S; Sano, J; Takagi, G; Takano, M1
Hasegawa, R; Hirata-Koizumi, M; Miyake, S; Saito, M; Urano, T1
Kumagai, K; Matsunaga, A; Noda, K; Saku, K; Zhang, B1
Hess, L; Krähenbühl, S; Krähenbühl-Melcher, A; Rätz Bravo, AE; Schlienger, RG; Tchambaz, L1
Arimochi, H; Hagiwara, M; Kataoka, K; Kuwahara, T; Nakayama, H; Ohnishi, Y1
Judge, HM; Peters, G; Smith, SM; Storey, RF1
Abrahamowicz, M; Austin, PC; Eisenberg, MJ; Humphries, K; Pilote, L; Rahme, E; Tu, JV; Zhou, Z1
Kawamori, R; Miwa, S; Nishiyama, K; Omura, C; Onuma, T; Takayanagi, N; Tanaka, Y; Watada, H1
Almeida, EA; Carneiro, A; Jorge, M; Jorge, PA; Ozaki, MR1
Battisti, WP; Brady, WE; Denke, MA; McBride, PE; Palmisano, J; Pearson, TA1
Iwano, C; Matsuyama, K; Matzno, S; Nishikata, M; Yasuda, N1
Iwashita, J; Kodama, S; Nakashima, M; Sasaki, H; Taniyama, K; Watanabe, M1
Corpataux, JM; London, NJ; Naik, J; Porter, KE1
Asberg, A; Hermann, M; Holdaas, H; Lemahieu, WP; Maes, BD; Vanrenterghem, Y; Verbeke, K1
Boehlen, F; Daali, Y; de Moerloose, P; Fontana, P; Mach, F; Reber, G; Senouf, D; Sigwart, U1
Carbonell, T; Freire, E1
Dieleman, JP; Dunselman, H; Straus, SM; Sturkenboom, MC; van Herpen, G; van Wijk, MA; van Wyk, JT1
Davidson, M1
Balice, M; Chironi, G; Del-Pino, M; Gariepy, J; Levenson, J; Simon, A1
Fonarow, GC1
Caspard, H; Chan, AK; Walker, AM1
Jadhav, SB; Jain, GK1
Heemann, U; Kohnle, M; Kribben, A; Philipp, T; Pietruck, F; Witzke, O1
Aoyama, T; Hara, S; Iwata, H; Kami, M; Kanda, Y; Matsuo, K; Mori, S; Murashige, N; Mutou, Y; Odawara, M; Suzuki, R; Tachibana, S; Takeuchi, K; Yamane, M1
Deray, G; Isnard-Bagnis, C; Karie, S; Launay-Vacher, V1
Demyanets, S; Hohensinner, PJ; Huber, K; Kaun, C; Maurer, G; Pammer, J; Pfaffenberger, S; Rega, G; Wojta, J1
Foody, JM; Galusha, D; Havranek, EP; Krumholz, HM; Masoudi, FA; Radford, MJ; Rathore, SS1
Plans-Rubió, P1
Serón, D1
Lachaine, J; Merikle, EP; Rinfret, S; Tarride, JE1
Adamovich, E; Allen, ZA; Butler, EG; Butler, WM; Galbreath, RW; Merrick, GS; Moyad, MA; Wallner, KE1
Abbas, T; Dutta, A; Sivaprasad, U1
Brecht, K; Kaufmann, P; Krähenbühl, S; Török, M; Waldhauser, KM; Zahno, A1
Neuvonen, PJ; Niemi, M; Pasanen, MK1
Bloom, ET; Horvath-Arcidiacono, JA; Porter, CM; Tanaka, T1
Akishita, M; Eto, M; Iijima, K; Kozaki, K; Nakano, T; Ouchi, Y; Son, BK1
Chen, J; Hashimoto, K; Mitsui, K; Nagasawa, Y; Shen, H; Tsurugi, K1
Brun, ME; Funk, C; Noé, J; Portmann, R1
Iwagaki, H; Kanke, T; Liu, K; Nishibori, M; Takahashi, HK; Tanaka, N; Yagi, T; Yoshino, T1
Batt, AM; Bertrand-Thiebault, C; Masson, C; Siest, G; Visvikis-Siest, S1
Bax, JJ; Davignon, J; Dunkelgrun, M; Feringa, HH; Hoeks, SE; Kastelein, JJ; Poldermans, D; Schouten, O; van Domburg, RT; Vidakovic, R; Welten, GM1
Honda, T; Kimura, J; Sakamoto, K; Waguri, S; Yokoya, S1
Angri, V; Calabrò, P; Chiariello, M; Cirillo, P; De Rosa, S; Fiorentino, I; Gargiulo, A; Musto D'Amore, S; Pacileo, M; Petrillo, G; Prevete, N; Sasso, L; Ucci, G1
Alsheikh-Ali, AA; Han, H; Karas, RH; Maddukuri, PV1
Deng, JW; Kim, KB; Liu, KH; Shin, JG; Shon, JH; Song, IS; Zhou, HH1
Blasetto, J; Gandhi, S; Harley, CR; Heien, H; Nelson, SP; Sasane, R1
Midgley, L; O'Regan, DJ; Porter, KE; Turner, NA1
Eng, C; Planchon, SM; Teresi, RE; Waite, KA1
Desamericq, G; Kieffer, A; Laforest, L; Le Jeunne, P; Moulin, P; Ritleng, C; Schwalm, MS; Souchet, T; Van Ganse, E1
Cappelleri, JC; Dubois, RW; Messerli, FH; Pinto, L; Sichrovsky, T; Tang, SS; Thakker, KM1
Asberg, A; Gedde-Dahl, A; Hejazifar, S; Hoel, K; Skottheim, IB1
Doney, AS; Donnan, PT; Donnelly, LA; Lang, CC; Morris, AD; Palmer, CN; Whitley, AL1
Gandhi, SK; Harley, CR; Heien, H; McDonough, K; Nelson, SP1
Brenner, H; Hahmann, H; Hoffmann, MM; Rothenbacher, D; Vossen, CY; Wüsten, B1
Cho, DY; Deng, JW; Shin, HJ; Shin, JG; Shon, JH; Song, IS; Yeo, CW1
Doggrell, SA1
Kimura, J; Mikami, H; Sakamoto, K1
Xiao, H; Yang, CS1
Backman, JT; Neuvonen, PJ; Niemi, M1
Avello L, M; Bravo D, M; Calvo M, C; Mennickent C, S1
Bienvenu, AL; Picot, S1
Mullangi, R; Srinivas, NR1
Freedland, SJ; Goldberg, KC; Hamilton, RJ; Platz, EA1
Arora, P; Devereaux, PJ; Mills, EJ; Perri, D; Rachlis, B; Wu, P1
Shen, J; Zhang, Q; Zhang, RY1
Ichihara, K; Itagaki, M; Kaneta, S; Kano, S; Satoh, K; Takaguri, A1
Glueck, CJ; Goldenberg, N; Khan, NA; Rawal, B; Wang, P; Yeramaneni, S1
Abel, T; Fehér, J1
Fitzgerald, K; Kashanin, D; O'Dowd, F; Robinson, AJ; Walsh, GM; Williams, V1
Backman, JT; Keskitalo, JE; Kurkinen, KJ; Neuvonen, M; Neuvonen, PJ; Niemi, M1
Bahadur, D; Panda, HS; Srivastava, R1
Keskitalo, JE; Neuvonen, PJ; Niemi, M; Pasanen, MK1
de Hoz, R; Mendez, T; Ramírez, AI; Ramírez, JM; Raposo, R; Redondo, A; Rojas, B; Salazar, JJ; Tejerina, T; Triviño, A1
Arranz Martínez, E; Gordillo López, FJ; Hermosa Hernán, JC; Ruiz García, A1
Abe, A; Katayama, Y; Katsura, K; Nagayama, H; Nishiyama, Y; Otsuka, T; Ueda, M1
Egawa, T; Hirabara, Y; Ikeda, M; Kataoka, Y; Kusaba, K; Mitsunaga, D; Shuto, H; Takano, Y; Tominaga, K; Yamauchi, A1
Ashour, S; Bahbouh, M; Khateeb, M1
D'Avolio, LW; Farwell, WR; Gaziano, JM; Lawler, EV; Scranton, RE1
Jia, Z; Li, Y; Misra, HP; Vandjelovic, N; Zhu, H; Zimmerman, RP1
Haughey, NJ; Maragakis, NJ; Murinson, BB1
Aukrust, P; Breland, UM; Hagelsteen, K; Halvorsen, B; Haraldsen, G; Hol, J; Kasprzycka, M; Otterdal, K; Pedersen, TM; Ranheim, T; Stang, E1
Dimbil, M; Golomb, BA; Hoffman, KB; Kraus, C1
Campbell, SM; Godman, B; Gustafsson, LL; Pichetti, S; Sermet, C1
Catapano, AL; Corrao, G; Ibrahim, B; Mancia, G; Merlino, L; Nicotra, F; Pasini, TS; Zambon, A1
Bátai-Konczos, A; Jemnitz, K; Kékesi, O; Kis, E; Szabó, K; Szabó, M; Veres, Z1
Cao, YJ; Du, HP; Hu, LF; Li, J; Liu, CF; Liu, H; Wang, F; Wang, YL; Xu, R; Xu, Y; You, SJ1
Albers, M; Baumeister, SE; Kroemer, HK; Meyer zu Schwabedissen, HE; Nauck, M; Rimmbach, C; Siegmund, W; Völzke, H; Wallaschofski, H1
Bailey, DG; Dixon, S; Fleet, JL; Gandhi, S; Garg, AX; Gomes, T; Juurlink, D; Kim, R; Li, DQ; Mamdani, M; McArthur, E; Shariff, SZ1
Assassi, AL; Auzerie, J; Gaudin, K; Hamon, T; Perovitch, P; Roy, CE1
Gandhi, HP; Patel, SS; Rathod, SP; Trivedi, JI; Variya, BC1
Banach, M; Bittner, V; Hovingh, GK; Kastelein, JJ; Lip, GY; Mikhailidis, DP; Ray, K; Rysz, J; Sahebkar, A; Serban, C; Undas, A; Ursoniu, S; Watts, GF1
Cheng, Z; Fu, SW; Hu, B; Ruan, LY; Wang, Y; Zheng, JN; Zheng, MH; Zhou, YY; Zhu, GQ1
Aldea, P; de Hoz, R; Fernández-Navarro, J; Gallego, BI; Ramírez, AI; Ramírez, JM; Rojas, B; Salazar, JJ; Tejerina, T; Triviño, A1
Asaumi, R; Kotani, N; Kusuhara, H; Maeda, K; Nakada, T; Sugiyama, Y; Toshimoto, K; Yoshida, K; Yoshikado, T1
Corkum, A; Fisher, J; Minard, LV; Saleh, A; Sketris, I; Zhang, Y1
Jiang, M; Liu, TT; Pan, DQ; Shi, JH; Wang, Q1
Bai, Y; Chan, C; Chang, X; Cheng, N; Cheng, Z; Lu, Y; Zhao, Y1
Añino Alba, A; Fernandez-Esteban, I; Fernandez-Tabera, JM; Gómez Álvarez, P; Izquierdo-Palomares, JM; Martin-Carrillo, P; Pinar López, Ó; Plana, MN; Saiz, LC1
Aganov, AV; Aganova, OV; Galiullina, LF; Klochkov, VV; Latfullin, IA; Musabirova, GS1
Anoopkumar-Dukie, S; Davey, AK; McFarland, AJ1
Apola, A; Kwiecień, A; Maślanka, A; Opoka, W; Stolarczyk, M1
Demyanets, S; Hohensinner, PJ; Huber, K; Kaun, C; Krychtiuk, KA; Lenz, M; Pentz, R; Stojkovic, S; Thaler, B; Wojta, J; Zuckermann, A1
Aganov, A; Galiullina, LF; Huster, D; Klochkov, V; Scheidt, HA1
Aschmann, HE; Kaufmann, M; Puhan, MA; Yebyo, HG1
Ahn, CM; Chang, HJ; Choi, D; Chun, KH; Ha, JW; Hong, GR; Hong, MK; Jang, Y; Kang, M; Kang, SM; Kim, BK; Kim, JS; Ko, YG; Lee, CJ; Lee, SH; Oh, J; Park, S; Roh, JW; Shim, CY1
de Fijter, JW; Dekker, FW; Dekkers, OM; Esmeijer, K; Hoogeveen, EK1
Attalah Nee Rezkallah, C; Chen, QM; Thongkum, A; Zhu, C1
Aksoy, HN; Ceylan, C1
Barwiolek, M; Budny, M; Ciarkowska, A; Kozakiewicz, A; Loch, JI; Sokolowska, Z; Wojtczak, A; Wujak, M1
Chen, B; Chen, SP; Cheng, RY; Lin, Y; Tsui, L; Xu, S; Ye, P1
Chen, WM; Shia, BC; Wu, SY; Yu, JM1
Filppula, AM; Hirvensalo, P; Keskitalo, J; Kiiski, JI; Lönnberg, KI; Mustaniemi, AL; Niemi, M; Tornio, A1
Cassola, N; Clezar, CN; Flumignan, CD; Flumignan, RL; Nakano, LC; Trevisani, VF1
Adams, SP; Alaeiilkhchi, N; Tasnim, S; Wright, JM1

Reviews

43 review(s) available for pravastatin and (3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

ArticleYear
Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, Aug-01, Volume: 52, Issue:15

    Topics: Anticholesteremic Agents; Biological Availability; Comorbidity; Drug Interactions; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Simvastatin

1995
[Cardiovascular pharmacology (VIII). The role of HMG CoA reductase inhibitors in the current treatment of hyperlipidemias].
    Revista espanola de cardiologia, 1995, Volume: 48, Issue:1

    Topics: Anticholesteremic Agents; Cardiovascular System; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lipoproteins; Lovastatin; Pravastatin; Simvastatin

1995
[The pharmacology of the statins: the evidence of a direct antiatherosclerotic action].
    Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna, 1995, Volume: 10 Suppl

    Topics: Animals; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Lovastatin; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin

1995
Benefits and risks of HMG-CoA reductase inhibitors in the prevention of coronary heart disease: a reappraisal.
    Drug safety, 1996, Volume: 14, Issue:1

    Topics: Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Simvastatin

1996
The role of isoprenoids in vascular smooth muscle: potential benefits of statins unrelated to cholesterol lowering.
    Journal of human hypertension, 1996, Volume: 10, Issue:6

    Topics: Animals; Anticholesteremic Agents; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Muscle, Smooth, Vascular; Pravastatin; Simvastatin

1996
Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.
    Clinical pharmacokinetics, 1996, Volume: 31, Issue:5

    Topics: Aged; Cholesterol; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins; Lovastatin; Male; Pravastatin; Pregnancy; Simvastatin

1996
Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences.
    Clinical pharmacokinetics, 1997, Volume: 32, Issue:5

    Topics: Anticholesteremic Agents; Arteriosclerosis; Brain; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Food-Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Liver; Lovastatin; Pravastatin; Simvastatin

1997
Maximizing the cost-effectiveness of lipid-lowering therapy.
    Archives of internal medicine, 1998, Oct-12, Volume: 158, Issue:18

    Topics: Anticholesteremic Agents; Atorvastatin; Carotid Stenosis; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Pyrroles; Simvastatin

1998
[The hyperlipidemias. Role of various statins].
    Presse medicale (Paris, France : 1983), 1999, Nov-20, Volume: 28, Issue:36

    Topics: Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin

1999
[Additional effects of statins independent of the cholesterol-lowering as yet not shown to be clinically relevant].
    Nederlands tijdschrift voor geneeskunde, 2000, Feb-12, Volume: 144, Issue:7

    Topics: Anticholesteremic Agents; Arteriosclerosis; Clinical Trials as Topic; Confounding Factors, Epidemiologic; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Simvastatin

2000
Non-lipid-related effects of statins.
    Annals of medicine, 2000, Volume: 32, Issue:3

    Topics: Animals; Arteriosclerosis; Blood Coagulation; Cholesterol; Cholesterol, LDL; Endothelium, Vascular; Esterification; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Simvastatin

2000
Statin trials in progress: unanswered questions.
    Current atherosclerosis reports, 2001, Volume: 3, Issue:1

    Topics: Atorvastatin; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hypolipidemic Agents; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin

2001
New statins and new doses of older statins.
    Current atherosclerosis reports, 2001, Volume: 3, Issue:1

    Topics: Atorvastatin; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hypolipidemic Agents; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2001
Effective use of statins to prevent coronary heart disease.
    American family physician, 2001, Jan-15, Volume: 63, Issue:2

    Topics: Atorvastatin; Cholesterol, LDL; Coronary Disease; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin

2001
Statin therapy--what now?
    Drug and therapeutics bulletin, 2001, Volume: 39, Issue:3

    Topics: Anticholesteremic Agents; Atorvastatin; Coronary Disease; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hyperlipidemias; Indoles; Patient Selection; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome

2001
A clinical focus on statins.
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:3

    Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Cost-Benefit Analysis; Down-Regulation; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Multicenter Studies as Topic; Myocardial Infarction; Practice Guidelines as Topic; Pravastatin; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Simvastatin

2001
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).
    European journal of clinical pharmacology, 2001, Volume: 57, Issue:5

    Topics: Atorvastatin; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin

2001
Managing dyslipidemia in the high-risk patient.
    The American journal of cardiology, 2002, Mar-07, Volume: 89, Issue:5A

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Bile Acids and Salts; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lovastatin; Niacin; Practice Guidelines as Topic; Pravastatin; Pyrimidines; Pyrroles; Risk; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Treatment Outcome; United States

2002
[Antilipemic agents in combined therapy].
    Orvosi hetilap, 2002, Aug-25, Volume: 143, Issue:34

    Topics: Anticholesteremic Agents; Apolipoproteins; Azetidines; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Drug Therapy, Combination; Ezetimibe; Fatty Acids, Monounsaturated; Fenofibrate; Fluvastatin; Folic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Indoles; Lipids; Pravastatin; Simvastatin; Triglycerides; Vitamin B 12; Vitamin B 6

2002
Treating dyslipidemia with statins: the risk-benefit profile.
    American heart journal, 2003, Volume: 145, Issue:3

    Topics: Atorvastatin; Cholesterol; Cholesterol, HDL; Coronary Disease; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hyperlipidemias; Indoles; Lovastatin; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Risk Assessment; Simvastatin; Stroke; Triglycerides; United States

2003
Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials.
    BMC family practice, 2003, Dec-01, Volume: 4

    Topics: Atorvastatin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Triglycerides

2003
Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:3

    Topics: Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Libido; Male; Middle Aged; Pravastatin

2004
Considerations in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation.
    Preventive cardiology, 2005,Fall, Volume: 8, Issue:4

    Topics: Atorvastatin; Comorbidity; Dyslipidemias; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney Failure, Chronic; Kidney Transplantation; Lovastatin; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2005
In-hospital initiation of statin therapy in acute coronary syndromes: maximizing the early and long-term benefits.
    Chest, 2005, Volume: 128, Issue:5

    Topics: Angina, Unstable; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Myocardial Ischemia; Pravastatin; Pyrroles; Syndrome; Treatment Outcome

2005
Statins and osteoporosis: new role for old drugs.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:1

    Topics: Animals; Atorvastatin; Bone and Bones; Clinical Trials as Topic; Drug Delivery Systems; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Fractures, Bone; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Osteogenesis; Osteoporosis; Pharmacokinetics; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Quinolines; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2006
[Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:2 Pt 1

    Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Cholesterol; Cholesterol, LDL; Dyslipidemias; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Graft Rejection; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Kidney Failure, Chronic; Liver Transplantation; Middle Aged; Pravastatin; Primary Prevention; Prospective Studies; Proteinuria; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Renal Dialysis; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Time Factors

2006
Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.
    Journal of the American College of Cardiology, 2007, Jul-31, Volume: 50, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Liver Diseases; Lovastatin; Neoplasms; Pravastatin; Rhabdomyolysis; Simvastatin

2007
Impact of systemic hypertension on the cardiovascular benefits of statin therapy--a meta-analysis.
    The American journal of cardiology, 2008, Feb-01, Volume: 101, Issue:3

    Topics: Aged; Atorvastatin; Cardiovascular Diseases; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Indoles; Male; Middle Aged; Pravastatin; Prognosis; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Therapeutics

2008
Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.
    Reviews on recent clinical trials, 2006, Volume: 1, Issue:2

    Topics: Amlodipine; Anticholesteremic Agents; Atorvastatin; Azetidines; Cardiovascular Diseases; Clinical Trials as Topic; Clofibric Acid; Ezetimibe; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Indoles; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2006
Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.
    International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Atorvastatin; Celecoxib; Colorectal Neoplasms; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Evidence-Based Medicine; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Meta-Analysis as Topic; Neoplasms; Pravastatin; Pyrazoles; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Sulfonamides; Sulindac

2008
Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.
    Clinical pharmacokinetics, 2008, Volume: 47, Issue:7

    Topics: Animals; Biological Availability; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Nonprescription Drugs; Pharmacogenetics; Pravastatin; Simvastatin

2008
[Pleiotropic effects of statins].
    Revista medica de Chile, 2008, Volume: 136, Issue:6

    Topics: Anticholesteremic Agents; Antioxidants; Atherosclerosis; Atorvastatin; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Oxidative Stress; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides

2008
Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:1

    Topics: Atorvastatin; Clopidogrel; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Indoles; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Ticlopidine

2009
Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.
    Journal of the American College of Cardiology, 2008, Nov-25, Volume: 52, Issue:22

    Topics: Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Confidence Intervals; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Risk

2008
The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials.
    Thrombosis and haemostasis, 2016, Volume: 115, Issue:3

    Topics: Adult; Aged; Antigens; Atherosclerosis; Atorvastatin; Cardiovascular Diseases; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Pravastatin; Randomized Controlled Trials as Topic; Regression Analysis; Risk Assessment; Rosuvastatin Calcium; Simvastatin; Thrombosis; von Willebrand Factor; Young Adult

2016
Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma.
    Oncotarget, 2016, Apr-19, Volume: 7, Issue:16

    Topics: Atorvastatin; Bayes Theorem; Carcinoma, Hepatocellular; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Liver Neoplasms; Lovastatin; Observational Studies as Topic; Pravastatin; Pyridines; Rosuvastatin Calcium; Simvastatin; Treatment Outcome

2016
Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis.
    Atherosclerosis, 2016, Volume: 254

    Topics: Anticholesteremic Agents; Atorvastatin; Bayes Theorem; Coronary Disease; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney Diseases; Lipids; Lovastatin; Muscles; Network Meta-Analysis; Patient Safety; Pravastatin; Quinolines; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome

2016
Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia.
    The Cochrane database of systematic reviews, 2016, 11-26, Volume: 11

    Topics: Anticholesteremic Agents; Drug Chronotherapy; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hyperlipidemias; Indoles; Lovastatin; Pravastatin; Randomized Controlled Trials as Topic; Simvastatin

2016
Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants.
    American heart journal, 2019, Volume: 210

    Topics: Atorvastatin; Cardiovascular Diseases; Cause of Death; Chemical and Drug Induced Liver Injury; Double-Blind Method; Fluvastatin; Headache; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Lovastatin; Middle Aged; Muscular Diseases; Nausea; Neoplasms; Network Meta-Analysis; Placebos; Pravastatin; Randomized Controlled Trials as Topic; Risk Assessment; Rosuvastatin Calcium; Simvastatin; Withholding Treatment

2019
Expanded table: statins.
    The Medical letter on drugs and therapeutics, 2019, Sep-23, Volume: 61, Issue:1581

    Topics: Anticholesteremic Agents; Delayed-Action Preparations; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Pravastatin; Statistics as Topic

2019
Effect of different types of statins on kidney function decline and proteinuria: a network meta-analysis.
    Scientific reports, 2019, 11-12, Volume: 9, Issue:1

    Topics: Atorvastatin; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Diseases; Lovastatin; Network Meta-Analysis; Pravastatin; Proteinuria; Rosuvastatin Calcium; Simvastatin; Treatment Outcome

2019
Pharmacological interventions for asymptomatic carotid stenosis.
    The Cochrane database of systematic reviews, 2023, 08-04, Volume: 8

    Topics: Aspirin; Atherosclerosis; Atorvastatin; Carotid Stenosis; Chlorthalidone; Fluvastatin; Hemorrhage; Humans; Ischemic Stroke; Metoprolol; Pravastatin; Probucol; Rosuvastatin Calcium; Stroke; Warfarin

2023
Pravastatin for lowering lipids.
    The Cochrane database of systematic reviews, 2023, 09-18, Volume: 9

    Topics: Atorvastatin; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Drug-Related Side Effects and Adverse Reactions; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant; Infant, Newborn; Pravastatin; Rosuvastatin Calcium

2023

Trials

32 trial(s) available for pravastatin and (3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

ArticleYear
Effects of fluvastatin and pravastatin on lipid profiles and thromboxane production in type IIa hypercholesterolemia.
    The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2

    Topics: Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipids; Male; Middle Aged; Placebos; Pravastatin; Single-Blind Method; Thromboxane A2; Thromboxane B2; Thromboxanes; Triglycerides

1995
Comparison of fluvastatin versus pravastatin treatment of primary hypercholesterolemia. French Fluvastatin Study Group.
    The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Anticholesteremic Agents; Aspartate Aminotransferases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatine Kinase; Double-Blind Method; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Male; Middle Aged; Placebos; Pravastatin; Triglycerides

1995
Fluvastatin versus pravastatin.
    The American journal of cardiology, 1996, Jul-01, Volume: 78, Issue:1

    Topics: Anticholesteremic Agents; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Pravastatin

1996
Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
    The American journal of cardiology, 1998, Mar-01, Volume: 81, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Simvastatin; Treatment Outcome

1998
Conversion to tacrolimus to ameliorate cyclosporine toxicity in kidney recipients.
    Transplantation proceedings, 1998, Volume: 30, Issue:5

    Topics: Adult; Aged; Anticholesteremic Agents; Cyclosporine; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gingival Hyperplasia; Hirsutism; Humans; Hyperlipidemias; Immunosuppressive Agents; Indoles; Kidney Transplantation; Lovastatin; Male; Middle Aged; Pravastatin; Tacrolimus

1998
Lowering effects of four different statins on serum triglyceride level.
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:7

    Topics: Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hypercholesterolemia; Indoles; Male; Middle Aged; Pravastatin; Pyrroles; Simvastatin; Treatment Outcome; Triglycerides

1999
Early introduction of HMG-CoA reductase inhibitors could prevent the incidence of transplant coronary artery disease.
    Transplantation proceedings, 2000, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Atorvastatin; Cholesterol; Coronary Disease; Fatty Acids, Monounsaturated; Female; Fluvastatin; Graft Rejection; Heart Transplantation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Lovastatin; Male; Middle Aged; Postoperative Complications; Pravastatin; Pyrroles; Simvastatin; Triglycerides

2000
Effect of fluconazole on plasma fluvastatin and pravastatin concentrations.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:3

    Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Female; Fluconazole; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Mixed Function Oxygenases; Pravastatin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

2000
Effects of cholestyramine on vitamin E levels in patients treated with statins.
    Journal of clinical pharmacology, 2000, Volume: 40, Issue:12 Pt 2

    Topics: Adult; Aged; Anticholesteremic Agents; Antioxidants; Cholesterol, LDL; Cholestyramine Resin; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Indoles; Lovastatin; Male; Middle Aged; Naphthalenes; Pravastatin; Simvastatin; Vitamin E

2000
Comparative study of HMG-CoA reductase inhibitors on fibrinogen.
    Atherosclerosis, 2001, Volume: 155, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Coronary Disease; Cross-Over Studies; Fatty Acids, Monounsaturated; Female; Fibrinogen; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Simvastatin

2001
Effects of 1-year treatment with fluvastatin or pravastatin on bone.
    The American journal of medicine, 2001, Volume: 110, Issue:7

    Topics: Aged; Anticholesteremic Agents; Bone and Bones; Bone Density; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Postmenopause; Pravastatin

2001
Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins.
    The American journal of medicine, 2001, Aug-15, Volume: 111, Issue:3

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Drug Administration Schedule; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Middle Aged; Patient Education as Topic; Pravastatin; Pyrroles; Risk; Risk Factors; Simvastatin; Treatment Outcome; Triglycerides; United States

2001
Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients.
    Atherosclerosis, 2002, Volume: 160, Issue:2

    Topics: Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Fluvastatin; Forearm; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Pravastatin; Prospective Studies; Vasodilation

2002
Effect of diet and treatment with statins on platelet-dependent thrombin generation in hypercholesterolemic subjects.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2001, Volume: 11, Issue:6

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Cholesterol; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hypercholesterolemia; Indoles; Male; Middle Aged; Pravastatin; Pyridines; Pyrroles; Simvastatin; Thrombin; Treatment Outcome

2001
Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients.
    Atherosclerosis, 2002, Volume: 164, Issue:2

    Topics: Adult; Aged; Apolipoprotein A-I; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Maximum Tolerated Dose; Middle Aged; Pravastatin; Probability; Pyrroles; Reference Values; Severity of Illness Index; Simvastatin; Single-Blind Method; Treatment Outcome

2002
Time-dependent effect of statins on platelet function in hypercholesterolaemia.
    European journal of clinical investigation, 2002, Volume: 32, Issue:12

    Topics: Adult; Analysis of Variance; Antiporters; Atorvastatin; Blood Platelets; Case-Control Studies; Cholesterol; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Linear Models; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide Synthase; P-Selectin; Platelet Activation; Pravastatin; Pyrroles; Simvastatin; Time Factors

2002
Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation.
    Arquivos brasileiros de cardiologia, 2003, Volume: 80, Issue:2

    Topics: Adult; Aged; Antioxidants; Coronary Artery Disease; Double-Blind Method; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipids; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Pravastatin

2003
An economic analysis of the Atorvastatin Comparative Cholesterol Efficacy and Safety Study (ACCESS).
    PharmacoEconomics, 2003, Volume: 21 Suppl 1

    Topics: Adult; Aged; Atorvastatin; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome

2003
Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects.
    The American journal of cardiology, 2004, Jan-01, Volume: 93, Issue:1

    Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Dose-Response Relationship, Drug; Fasting; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Indoles; Lipoproteins; Lovastatin; Male; Middle Aged; Postprandial Period; Pravastatin; Pyrroles; Simvastatin; Triglycerides

2004
Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir.
    Infection, 2004, Volume: 32, Issue:4

    Topics: Adult; Anticholesteremic Agents; Antiretroviral Therapy, Highly Active; Fatty Acids, Monounsaturated; Female; Fluvastatin; HIV Infections; HIV Protease Inhibitors; Humans; Hypercholesterolemia; Indinavir; Indoles; Male; Middle Aged; Pravastatin; Prospective Studies; Treatment Outcome

2004
Long-term effects of statins on arterial pressure and stiffness of hypertensives.
    Journal of human hypertension, 2005, Volume: 19, Issue:2

    Topics: Anticholesteremic Agents; Arteriosclerosis; Blood Pressure; C-Reactive Protein; Cholesterol; Elasticity; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemias; Hypertension; Indoles; Male; Middle Aged; Pravastatin; Prospective Studies; Pulsatile Flow; Simvastatin; Single-Blind Method

2005
Effects of statins on circulating oxidized low-density lipoprotein in patients with hypercholesterolemia.
    Japanese heart journal, 2004, Volume: 45, Issue:6

    Topics: Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Prospective Studies

2004
A comparative crossover study of the effects of fluvastatin and pravastatin (FP-COS) on circulating autoantibodies to oxidized LDL in patients with hypercholesterolemia.
    Journal of atherosclerosis and thrombosis, 2005, Volume: 12, Issue:1

    Topics: Autoantibodies; Cross-Over Studies; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipoproteins, LDL; Pravastatin

2005
A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial.
    Mayo Clinic proceedings, 2005, Volume: 80, Issue:5

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Azetidines; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Nephelometry and Turbidimetry; Practice Guidelines as Topic; Pravastatin; Pyrroles; Retrospective Studies; Risk Factors; Simvastatin

2005
Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:9

    Topics: Area Under Curve; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indoles; Lactones; Liver; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Pravastatin; Pyrroles; Simvastatin; Tacrolimus; Time Factors

2005
Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Azetidines; Cholesterol; Cyclosporine; Drug Therapy, Combination; Ezetimibe; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Kidney Transplantation; Liver; Male; Middle Aged; Muscle, Skeletal; Pravastatin; Simvastatin; Tacrolimus

2006
SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:4

    Topics: Adult; Anticholesteremic Agents; Area Under Curve; Cross-Over Studies; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Polymorphism, Genetic; Pravastatin; Prospective Studies; Reference Values; Sex Characteristics; Sex Factors

2006
Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy.
    Atherosclerosis, 2008, Volume: 199, Issue:2

    Topics: Aged; Anticholesteremic Agents; Cardiovascular System; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipids; Male; Middle Aged; Pravastatin; Pyrimidines; Risk Factors; Rosuvastatin Calcium; Sulfonamides; Treatment Outcome

2008
The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.
    Pharmacogenetics and genomics, 2008, Volume: 18, Issue:5

    Topics: Adult; Anticholesteremic Agents; Biological Transport; Cross-Over Studies; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Inactivation, Metabolic; Indoles; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Oocytes; Organic Anion Transporters; Polymorphism, Single Nucleotide; Pravastatin; Protein Binding; Quinolines; Substrate Specificity

2008
[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina].
    Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:9

    Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angina Pectoris; Atorvastatin; Clopidogrel; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Pravastatin; Prospective Studies; Pyrroles; Ticlopidine

2008
Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?
    Metabolism: clinical and experimental, 2009, Volume: 58, Issue:2

    Topics: Atorvastatin; Cholesterol, LDL; Creatine Kinase; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Prospective Studies; Pyrimidines; Pyrroles; Rhabdomyolysis; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2009
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.
    Journal of atherosclerosis and thrombosis, 2011, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Linear Models; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Quinolines; Stroke

2011

Other Studies

164 other study(ies) available for pravastatin and (3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

ArticleYear
Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase.
    Biochemical and biophysical research communications, 1990, Jul-31, Volume: 170, Issue:2

    Topics: Animals; Atorvastatin; Carcinoma, Hepatocellular; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Fibroblasts; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver Neoplasms; Lovastatin; Male; Naphthalenes; Pravastatin; Pyrroles; Rats; Rats, Inbred Strains; Sterols; Tetrazoles; Tumor Cells, Cultured

1990
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
    The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2

    Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin

1995
Inhibition of cholesterol synthesis ex vivo and in vivo by fluvastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Experientia, 1995, Mar-15, Volume: 51, Issue:3

    Topics: Acetates; Animals; Anticholesteremic Agents; Carbon Radioisotopes; Cholesterol; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; Indoles; Kidney; Kinetics; Liver; Male; Organ Specificity; Pravastatin; Rats; Rats, Wistar; Sterols

1995
Species differences in the inhibiting effect of fluvastatin, a new inhibitor of HMG-CoA reductase, on cholesterol biosynthesis.
    Research communications in molecular pathology and pharmacology, 1994, Volume: 86, Issue:3

    Topics: Animals; Anticholesteremic Agents; Cholesterol; Cricetinae; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; Indoles; Kidney; Liver; Male; Mesocricetus; Pravastatin; Rats; Rats, Wistar; Species Specificity

1994
Fluvastatin cost considerations.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:9

    Topics: Drug Costs; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Simvastatin

1994
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.
    Atherosclerosis, 1993, Volume: 101, Issue:1

    Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes

1993
HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits.
    Arteriosclerosis and thrombosis : a journal of vascular biology, 1993, Volume: 13, Issue:4

    Topics: Animals; Carotid Arteries; Cell Division; Cholesterol; Fatty Acids, Monounsaturated; Fluorescent Antibody Technique; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Lovastatin; Male; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Reference Values; Simvastatin

1993
Cost of lipid-lowering statin drugs.
    The American journal of cardiology, 1996, Jan-15, Volume: 77, Issue:2

    Topics: Anticholesteremic Agents; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Simvastatin

1996
Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation.
    Archives of biochemistry and biophysics, 1996, Jan-15, Volume: 325, Issue:2

    Topics: Animals; Anticholesteremic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Male; Pravastatin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, LDL; RNA, Messenger; Tricarboxylic Acids

1996
Inadequate treatment with HMG-CoA reductase inhibitors by health care providers.
    The American journal of medicine, 1996, Volume: 100, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lovastatin; Male; Middle Aged; Patient Selection; Pravastatin; Retrospective Studies; Treatment Outcome

1996
In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors.
    European journal of clinical pharmacology, 1996, Volume: 50, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoenzymes; Lovastatin; Microsomes, Liver; Mixed Function Oxygenases; Pravastatin; Simvastatin; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

1996
Inhibition of isoprenoid biosynthesis and arterial smooth-muscle cell proliferation.
    Journal of cardiovascular pharmacology, 1995, Volume: 25 Suppl 4

    Topics: Animals; Anticholesteremic Agents; Bromodeoxyuridine; Carotid Arteries; Cell Division; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluorescent Antibody Technique, Indirect; Fluvastatin; Image Processing, Computer-Assisted; Indoles; Infusion Pumps, Implantable; Injections, Intraperitoneal; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Simvastatin

1995
Cost effectiveness of lowering cholesterol. Statin treatment should be started early.
    BMJ (Clinical research ed.), 1996, Nov-02, Volume: 313, Issue:7065

    Topics: Cardiovascular Diseases; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Simvastatin

1996
Effects of two different HMG-CoA reductase inhibitors on thromboxane production in type IIA hypercholesterolemia.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1996, Volume: 50, Issue:6-7

    Topics: Anticholesteremic Agents; Cholesterol; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Indoles; Lipids; Male; Middle Aged; Pravastatin; Thromboxane B2

1996
Inhibitory effect of fluvastatin at doses insufficient to lower serum lipids on the catheter-induced thickening of intima in rabbit femoral artery.
    European journal of pharmacology, 1996, Nov-07, Volume: 315, Issue:1

    Topics: Animals; Anticholesteremic Agents; Catheterization; Cholesterol; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Indoles; Lipids; Male; Mevalonic Acid; Phospholipids; Pravastatin; Rabbits; Triglycerides; Tunica Intima

1996
Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line.
    International journal of immunopharmacology, 1996, Volume: 18, Issue:11

    Topics: Cell Adhesion Molecules; Cell Line; Depression, Chemical; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Monounsaturated; Flow Cytometry; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Indoles; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Mevalonic Acid; Monocytes; Pravastatin; Umbilical Veins

1996
The rule of 5 and the rule of 7 in lipid-lowering by statin drugs.
    The American journal of cardiology, 1997, Jul-01, Volume: 80, Issue:1

    Topics: Anticholesteremic Agents; Atorvastatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Pravastatin; Pyrroles; Simvastatin

1997
[The mechanism of action of hypolipidemic drugs].
    Revue medicale de Liege, 1997, Volume: 52, Issue:6

    Topics: Adipose Tissue; Anticholesteremic Agents; Cholesterol, LDL; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Hypolipidemic Agents; Indoles; Lipase; Lipid Peroxidation; Lipoproteins, VLDL; Liver; Lovastatin; Microbodies; Nuclear Proteins; Pravastatin; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Simvastatin; Transcription Factors

1997
Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats.
    Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:8

    Topics: Animals; Anticholesteremic Agents; Cell Adhesion; Cell Movement; Cholesterol, Dietary; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Leukocytes; Leukotriene B4; Male; Platelet Activating Factor; Pravastatin; Rats; Rats, Sprague-Dawley

1997
Proapoptotic effect of atorvastatin on stimulated rabbit smooth muscle cells.
    Pharmacological research, 1997, Volume: 36, Issue:2

    Topics: Animals; Apoptosis; Atorvastatin; Carotid Stenosis; Cell Division; Cells, Cultured; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Muscle, Smooth, Vascular; Pravastatin; Pyrroles; Rabbits; Simvastatin

1997
Direct effects of statins on the vascular wall.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:5

    Topics: Adult; Aged; Anticholesteremic Agents; Cell Division; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Male; Middle Aged; Muscle, Smooth, Vascular; Myocardium; Pravastatin

1998
Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
    The American journal of cardiology, 1998, Aug-01, Volume: 82, Issue:3

    Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome

1998
Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes.
    European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1

    Topics: Animals; Anticholesteremic Agents; Antioxidants; Butylated Hydroxytoluene; Cytochrome P-450 Enzyme System; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Peroxidation; Male; Microsomes, Liver; Pravastatin; Probucol; Rats; Rats, Sprague-Dawley; Superoxides

1998
[Antioxidative effects of fluvastatin, and its major metabolites].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1999, Volume: 119, Issue:1

    Topics: Animals; Antioxidants; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Peroxidation; Microsomes, Liver; Pravastatin; Rats

1999
Statins and PHARMAC.
    The New Zealand medical journal, 1999, Feb-26, Volume: 112, Issue:1082

    Topics: Anticholesteremic Agents; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Pravastatin; Publishing; Simvastatin; Treatment Outcome

1999
Two different types of exercise-induced muscle pain without myopathy and CK-elevation during HMG-Co-enzyme-A-reductase inhibitor treatment.
    Atherosclerosis, 1999, Volume: 143, Issue:2

    Topics: Adolescent; Adult; Creatine Kinase; Dose-Response Relationship, Drug; Exercise; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Indoles; Lovastatin; Male; Middle Aged; Muscle Cramp; Muscle, Skeletal; Pain; Pravastatin; Prognosis; Risk Assessment; Simvastatin; Sports

1999
The change of cost: reference-based pricing and the statins.
    The Canadian journal of cardiology, 1999, Volume: 15, Issue:5

    Topics: Anticholesteremic Agents; Canada; Cardiovascular Diseases; Drug Costs; Economics, Pharmaceutical; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; Pravastatin; Simvastatin

1999
Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders.
    American heart journal, 1999, Volume: 138, Issue:1 Pt 1

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Indoles; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Simvastatin; Time Factors; Treatment Outcome

1999
The effects of changing statins on cholesterol levels.
    The New Zealand medical journal, 1999, Jul-09, Volume: 112, Issue:1091

    Topics: Anticholesteremic Agents; Cholesterol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; New Zealand; Practice Patterns, Physicians'; Pravastatin; Simvastatin; Treatment Outcome

1999
Comparative toxicity of high doses of vastatins currently used by clinicians, in CD-1 male mice fed with a hypercholesterolemic diet.
    Life sciences, 1999, Volume: 65, Issue:9

    Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Cholesterol, Dietary; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipids; Liver; Lovastatin; Male; Mice; Mice, Inbred Strains; Organ Size; Pravastatin; Simvastatin; Time Factors; Transaminases; Triglycerides

1999
[Are all HMG-CoA reductase inhibitors protective against ischemic heart disease?].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1

    Topics: Adenosine Triphosphate; Animals; Atorvastatin; Dogs; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Myocardial Contraction; Myocardial Ischemia; Myocardial Stunning; Myocardium; Pravastatin; Pyridines; Pyrroles; Simvastatin

1999
Fluvastatin suppresses atherosclerotic progression, mediated through its inhibitory effect on endothelial dysfunction, lipid peroxidation, and macrophage deposition.
    Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:1

    Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cholesterol, Dietary; Disease Progression; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Hemolytic Plaque Technique; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Peroxidation; Lipid Peroxides; Lipids; Macrophages; Male; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Thiobarbituric Acid Reactive Substances

2000
Which statin is most efficient for the treatment of hypercholesterolemia? A cost-effectiveness analysis.
    Clinical therapeutics, 1999, Volume: 21, Issue:11

    Topics: Administration, Oral; Algorithms; Cholesterol, LDL; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Models, Economic; Pravastatin; Simvastatin; Treatment Outcome

1999
HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:2

    Topics: Animals; Atorvastatin; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Microsomes, Liver; Pravastatin; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Species Specificity

2000
Fluvastatin normalizes the decreased turnovers of glutathione and ascorbic acid in Watanabe heritable hyperlipidaemic rabbits.
    Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:9

    Topics: Animals; Anticholesteremic Agents; Antimetabolites; Ascorbic Acid; Buthionine Sulfoximine; Cholesterol; Fatty Acids, Monounsaturated; Fluvastatin; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Kidney; Liver; Male; Oxidation-Reduction; Phospholipids; Pravastatin; Rabbits; Thiobarbituric Acid Reactive Substances; Triglycerides

2000
Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:3

    Topics: Analysis of Variance; Anticholesteremic Agents; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Matrix Metalloproteinase 1; Mevalonic Acid; Polyisoprenyl Phosphates; Pravastatin; Sesquiterpenes; Squalene; Time Factors; Tissue Inhibitor of Metalloproteinase-1

2000
Development of tachyphylaxis among patients taking HMG CoA reductase inhibitors.
    The American journal of cardiology, 2000, Nov-15, Volume: 86, Issue:10

    Topics: Atorvastatin; Cholesterol, LDL; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Least-Squares Analysis; Linear Models; Lovastatin; Nonlinear Dynamics; Pravastatin; Pyrroles; Retrospective Studies; Simvastatin; Tachyphylaxis; Time Factors

2000
Lipid treatment goals achieved in patients treated with statin drugs in Norwegian general practice.
    The American journal of cardiology, 2000, Dec-01, Volume: 86, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Family Practice; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipids; Male; Middle Aged; Norway; Pravastatin; Pyridines; Pyrroles; Retrospective Studies; Simvastatin; Surveys and Questionnaires

2000
[Which statin is more efficient? Concepts and applications in economic evaluation].
    Atencion primaria, 2000, Sep-30, Volume: 26, Issue:5

    Topics: Anticholesteremic Agents; Cost-Benefit Analysis; Costs and Cost Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Lovastatin; Pravastatin; Simvastatin

2000
Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits.
    Circulation, 2001, Feb-20, Volume: 103, Issue:7

    Topics: Animals; Arteriosclerosis; Azo Compounds; Cell Division; Cells, Cultured; Collagen; Coloring Agents; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Immunohistochemistry; Indoles; Lipids; Macrophages; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Muscle, Smooth; Pravastatin; Procollagen; Rabbits; RNA, Messenger

2001
[Antioxidative effects of fluvastatin, and its major metabolites [II]].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2001, Volume: 121, Issue:1

    Topics: Animals; Anticholesteremic Agents; Cells, Cultured; Depression, Chemical; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Peroxidation; Microsomes, Liver; Pravastatin; Probucol; Simvastatin; Stereoisomerism; Structure-Activity Relationship

2001
Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis.
    Free radical research, 2001, Volume: 34, Issue:1

    Topics: Bacteriophages; DNA Damage; DNA, Single-Stranded; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Mutagenesis; Mutagenicity Tests; Oxidative Stress; Pravastatin; Reactive Oxygen Species; Salmonella typhimurium; Simvastatin

2001
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.
    The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:2

    Topics: Antioxidants; Butylated Hydroxytoluene; Fatty Acids, Monounsaturated; Fluvastatin; Free Radicals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Iron; Lipid Peroxidation; Liposomes; Oxidants; Oxygen Consumption; Phospholipids; Pravastatin; Probucol

2001
Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction.
    Kidney international, 2001, Volume: 59, Issue:6

    Topics: Actins; Animals; Cholesterol; Disease Models, Animal; Fatty Acids, Monounsaturated; Fibrosis; Fluvastatin; Gene Expression; Glycation End Products, Advanced; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney; Membrane Proteins; Mice; Nephritis, Interstitial; Oxidative Stress; Pravastatin; RNA, Messenger; Triglycerides; Ureteral Obstruction

2001
Statin induced myopathy does not show up in MIBI scintigraphy.
    Nuclear medicine communications, 2001, Volume: 22, Issue:5

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Breast Neoplasms; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Indoles; Lovastatin; Male; Middle Aged; Muscle, Skeletal; Muscular Diseases; Pain; Pravastatin; Pyridines; Pyrroles; Radionuclide Imaging; Radiopharmaceuticals; Simvastatin; Technetium Tc 99m Sestamibi

2001
HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress.
    Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:6

    Topics: Antioxidants; Cell Movement; Cells, Cultured; Coronary Artery Disease; Coronary Vessels; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoenzymes; Lysophosphatidylcholines; Mevalonic Acid; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Oxidative Stress; Phospholipase D; Pravastatin; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein-Tyrosine Kinases; Simvastatin

2001
A cost-effectiveness model of alternative statins to achieve target LDL-cholesterol levels.
    International journal of clinical practice, 2001, Volume: 55, Issue:4

    Topics: Atorvastatin; Cholesterol, LDL; Coronary Disease; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Models, Economic; Pravastatin; Pyridines; Pyrroles; Simvastatin

2001
Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins.
    Atherosclerosis, 2001, Volume: 157, Issue:1

    Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Muscle, Smooth, Vascular; Pravastatin; Rabbits

2001
Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.
    Life sciences, 2001, Aug-10, Volume: 69, Issue:12

    Topics: Animals; Antioxidants; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Microsomes, Liver; Oxygen; Pravastatin; Probucol; Rats; Reactive Oxygen Species; Simvastatin; Singlet Oxygen; Vitamin E

2001
Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts.
    Transplantation, 2001, Sep-27, Volume: 72, Issue:6

    Topics: Animals; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endocardium; Everolimus; Fatty Acids, Monounsaturated; Fluvastatin; Heart Transplantation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indoles; Male; Monocytes; Myocardium; Pravastatin; Rats; Rats, Inbred F344; Rats, Inbred Lew; Sirolimus

2001
Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis.
    Circulation, 2001, Oct-30, Volume: 104, Issue:18

    Topics: Aged; Aortic Valve Stenosis; Atorvastatin; Calcinosis; Cholesterol, HDL; Cholesterol, LDL; Disease Progression; Echocardiography; Electrocardiography; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Multivariate Analysis; Pravastatin; Pyrroles; Retrospective Studies; Risk Factors; Simvastatin; Treatment Outcome; Triglycerides; Vascular Patency

2001
Managed care trends in statin usage.
    Managed care (Langhorne, Pa.), 2001, Volume: 10, Issue:10

    Topics: Anticholesteremic Agents; Atorvastatin; Databases, Factual; Drug Costs; Drug Utilization Review; Fatty Acids, Monounsaturated; Fluvastatin; Health Care Sector; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lovastatin; Managed Care Programs; Pravastatin; Pyridines; Pyrroles; Simvastatin; United States

2001
Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells.
    Chinese medical journal, 2001, Volume: 114, Issue:11

    Topics: Animals; Cells, Cultured; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-1; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Sprague-Dawley

2001
The use over time of statins in coronary patients in an Italian tertiary referral center.
    Italian heart journal : official journal of the Italian Federation of Cardiology, 2001, Volume: 2, Issue:11

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; C-Reactive Protein; Cholesterol, LDL; Coronary Artery Disease; Drug Utilization Review; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Italy; Male; Middle Aged; Practice Patterns, Physicians'; Pravastatin; Pyrroles; Retrospective Studies; Risk Factors; Simvastatin

2001
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.
    Methods and findings in experimental and clinical pharmacology, 2001, Volume: 23, Issue:7

    Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Calcium; Cell Line; Core Binding Factor Alpha 1 Subunit; Core Binding Factors; Fatty Acids, Monounsaturated; Fluvastatin; GTPase-Activating Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Lovastatin; Mevalonic Acid; Mice; Neoplasm Proteins; Osteoblasts; Osteogenesis; Phosphates; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Sesquiterpenes; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured

2001
Fluvastatin enhances apoptosis in cytokine-stimulated vascular smooth muscle cells.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:2

    Topics: Animals; Aorta, Thoracic; Apoptosis; Blotting, Western; Caspase Inhibitors; Caspases; Cells, Cultured; DNA Fragmentation; Fatty Acids, Monounsaturated; Flow Cytometry; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-1; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Pravastatin; Protein Prenylation; Rats; Rats, Sprague-Dawley

2002
Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins.
    Annals of the New York Academy of Sciences, 2001, Volume: 947

    Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Disease Models, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Lipids; Pravastatin; Rabbits

2001
Safety and efficacy of atorvastatin in heart transplant recipients.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2002, Volume: 21, Issue:2

    Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Creatine Kinase; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Glucocorticoids; Heart Transplantation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Pravastatin; Prednisone; Pyrroles; Retrospective Studies; Treatment Outcome

2002
Effect of fluvastatin and pravastatin, HMG-CoA reductase inhibitors, on fluconazole activity against Candida albicans.
    Journal of medical microbiology, 2002, Volume: 51, Issue:2

    Topics: Antifungal Agents; Candida albicans; Drug Synergism; Fatty Acids, Monounsaturated; Fluconazole; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Microbial Sensitivity Tests; Pravastatin

2002
Statins and risk of polyneuropathy: a case-control study.
    Neurology, 2002, May-14, Volume: 58, Issue:9

    Topics: Aged; Case-Control Studies; Causality; Denmark; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Logistic Models; Lovastatin; Male; Middle Aged; Odds Ratio; Polyneuropathies; Pravastatin; Registries; Risk; Risk Assessment; Simvastatin

2002
HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells.
    Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:2

    Topics: ADP Ribose Transferases; Amides; Analysis of Variance; Animals; Botulinum Toxins; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-6; Intracellular Signaling Peptides and Proteins; Lovastatin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pravastatin; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger

2002
Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells.
    Atherosclerosis, 2002, Volume: 165, Issue:1

    Topics: Analysis of Variance; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-8; Muscle, Smooth, Vascular; Pravastatin; Probability; Pyridines; RNA, Messenger; Sensitivity and Specificity

2002
The HMG Co-A reductase inhibitors ('statins') and myotoxic effects.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2002, Volume: 92, Issue:8

    Topics: Atorvastatin; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Muscular Diseases; Myositis; Pravastatin; Pyrroles; Rhabdomyolysis; Simvastatin

2002
Severe rhabdomyolysis after laparoscopic surgery for adenocarcinoma of the rectum in two patients treated with statins.
    Anesthesiology, 2002, Volume: 97, Issue:4

    Topics: Adenocarcinoma; Creatine Kinase; Creatinine; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Laparoscopy; Male; Middle Aged; Paralysis; Postoperative Complications; Pravastatin; Rectal Neoplasms; Rectum; Rhabdomyolysis

2002
Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:10

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Blood Glucose; Blood Urea Nitrogen; Creatinine; Deoxyguanosine; Diabetes Mellitus, Experimental; DNA; DNA Damage; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Pravastatin; Simvastatin; Weight Gain

2002
Fluvastatin induces apoptosis in rat neonatal cardiac myocytes: a possible mechanism of statin-attenuated cardiac hypertrophy.
    Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:6

    Topics: Animals; Animals, Newborn; Apoptosis; Cardiomegaly; Cells, Cultured; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Indoles; Monomeric GTP-Binding Proteins; Myocytes, Cardiac; Pravastatin; Rats; Rats, Sprague-Dawley; Signal Transduction

2002
Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.
    Molecular pharmacology, 2003, Volume: 63, Issue:4

    Topics: Aryldialkylphosphatase; Carboxylic Ester Hydrolases; DNA; Esterases; Fatty Acids, Monounsaturated; Fenofibrate; Fluvastatin; Gene Expression Regulation, Enzymologic; Humans; Hypolipidemic Agents; Indoles; Pravastatin; Promoter Regions, Genetic; RNA, Messenger; Simvastatin; Tumor Cells, Cultured

2003
A model to assess the cost effectiveness of statins in achieving the UK National Service Framework target cholesterol levels.
    PharmacoEconomics, 2003, Volume: 21 Suppl 1

    Topics: Atorvastatin; Cholesterol; Clinical Trials as Topic; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Models, Economic; Pravastatin; Pyrroles; Simvastatin; United Kingdom

2003
The sorry saga of the statins in New Zealand--pharmacopolitics versus patient care.
    The New Zealand medical journal, 2003, Mar-14, Volume: 116, Issue:1170

    Topics: Drug Industry; Fatty Acids, Monounsaturated; Fees, Pharmaceutical; Fluvastatin; Government Agencies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Insurance Coverage; Insurance, Pharmaceutical Services; National Health Programs; New Zealand; Politics; Pravastatin; Rate Setting and Review; Simvastatin

2003
Statins inhibit high glucose-mediated neutrophil-endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide.
    Microvascular research, 2003, Volume: 65, Issue:2

    Topics: Cell Adhesion; Cells, Cultured; E-Selectin; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; P-Selectin; Pravastatin; Protein Kinase C; Umbilical Veins

2003
Variable influence of statins on isoprostanes in hyperlipidemia.
    Advances in experimental medicine and biology, 2003, Volume: 525

    Topics: Adult; Anticholesteremic Agents; Atorvastatin; Dinoprost; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Isoprostanes; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Simvastatin; Smoking

2003
Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes.
    Diabetes care, 2003, Volume: 26, Issue:6

    Topics: Atorvastatin; Cholesterol, LDL; Coronary Disease; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Reproducibility of Results; Sensitivity and Specificity; Simvastatin; United States

2003
Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:6

    Topics: Administration, Oral; Animals; Antioxidants; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Fatty Acids, Monounsaturated; Fluvastatin; In Vitro Techniques; Indoles; Male; NADPH Oxidases; Neutrophils; Pravastatin; Rats; Rats, Wistar; Reactive Oxygen Species; Tetradecanoylphorbol Acetate

2003
Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins.
    Acta cardiologica, 2003, Volume: 58, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fibric Acids; Fluvastatin; Heptanoic Acids; Humans; Hyperlipidemias; Indoles; Male; Microfilament Proteins; Middle Aged; Muscle Proteins; Pravastatin; Pyrroles; Retrospective Studies

2003
Effects of statins on adhesion molecule expression in endothelial cells.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:11

    Topics: Cell Adhesion Molecules; E-Selectin; Endothelium, Vascular; Fatty Acids, Monounsaturated; Flow Cytometry; Fluvastatin; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Saphenous Vein; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1

2003
Effect of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:1

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Aryldialkylphosphatase; Cholesterol; Fatty Acids, Monounsaturated; Fluvastatin; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Male; Pravastatin; Rats; Rats, Wistar

2004
Toward a role for statins in immunomodulation.
    Molecular interventions, 2002, Volume: 2, Issue:8

    Topics: Adjuvants, Immunologic; Animals; Atorvastatin; Autoimmune Diseases; Cytokines; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Genes, MHC Class II; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indoles; Lovastatin; Mice; Pravastatin; Pyrroles; Simvastatin

2002
Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Jun-01, Volume: 101, Issue:22

    Topics: Animals; Anti-Inflammatory Agents; Cell Division; Cell Line; Cyclic GMP; Electron Spin Resonance Spectroscopy; Fatty Acids, Monounsaturated; Fluvastatin; Hemoglobins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Macrophages; Mice; Molecular Structure; Myocytes, Smooth Muscle; Nitric Oxide; Nitrites; Pravastatin; Rats

2004
Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively.
    The American journal of cardiology, 2004, Jul-01, Volume: 94, Issue:1

    Topics: Aged; Aged, 80 and over; Arteriosclerosis; Atorvastatin; Carotid Artery Diseases; Endarterectomy, Carotid; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukins; Male; Matrix Metalloproteinases; Middle Aged; Pravastatin; Pyrroles; Simvastatin; Tissue Inhibitor of Metalloproteinases; Tumor Necrosis Factor-alpha; Ultrasonography

2004
Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.
    Journal of cellular biochemistry, 2004, Nov-15, Volume: 93, Issue:5

    Topics: Antineoplastic Agents; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cell Proliferation; Cell Shape; Cell Survival; Cisplatin; Doxorubicin; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Mesenchymal Stem Cells; Neuroglia; Phenotype; Polyisoprenyl Phosphates; Pravastatin; Transforming Growth Factor beta

2004
Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.
    Journal of leukocyte biology, 2005, Volume: 77, Issue:3

    Topics: Antibodies, Monoclonal; CD40 Antigens; Cell Differentiation; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-18; Kinetics; Mevalonic Acid; Monocytes; Naphthalenes; Pravastatin; Tosylphenylalanyl Chloromethyl Ketone; Tumor Necrosis Factor-alpha

2005
A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan.
    Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:1

    Topics: Area Under Curve; Atorvastatin; Biomedical Research; Databases, Bibliographic; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Japan; Pharmacology, Clinical; Pravastatin; Product Labeling; Pyrroles; Quinolines; Simvastatin; United States; United States Food and Drug Administration

2005
Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy.
    Drug safety, 2005, Volume: 28, Issue:3

    Topics: Aged; Ambulatory Care; Aryl Hydrocarbon Hydroxylases; Atorvastatin; Comorbidity; Cross-Sectional Studies; Cyclosporine; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Male; Niacin; Oxidoreductases, N-Demethylating; Physicians; Pravastatin; Prevalence; Product Surveillance, Postmarketing; Pyrroles; Simvastatin; Time Factors

2005
Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.
    World journal of gastroenterology, 2005, Feb-21, Volume: 11, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atorvastatin; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileal Diseases; Ileum; Indoles; Male; Pravastatin; Pyrroles; Rats; Rats, Wistar; Ulcer

2005
Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention.
    Platelets, 2004, Volume: 15, Issue:8

    Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Atorvastatin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Simvastatin; Ticlopidine

2004
Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2005, Apr-26, Volume: 172, Issue:9

    Topics: Aged; Atorvastatin; Cohort Studies; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mortality; Myocardial Infarction; Patient Compliance; Pravastatin; Proportional Hazards Models; Pyrroles; Retrospective Studies; Secondary Prevention; Simvastatin; Survival Analysis

2005
Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients.
    Endocrine journal, 2005, Volume: 52, Issue:2

    Topics: Aged; Antioxidants; Cholestenes; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Erythrocyte Membrane; Fatty Acids, Monounsaturated; Female; Fluvastatin; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypoglycemic Agents; Indoles; Male; Middle Aged; Oxidative Stress; Pravastatin; Prospective Studies; Simvastatin; Thiobarbituric Acid Reactive Substances

2005
[Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits].
    Arquivos brasileiros de cardiologia, 2005, Volume: 84, Issue:4

    Topics: Animals; Anticholesteremic Agents; Aortic Diseases; Arteriosclerosis; Atorvastatin; Cholesterol; Cholesterol, LDL; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hypercholesterolemia; Indoles; Lipid Peroxidation; Male; Malondialdehyde; Pravastatin; Pyrroles; Rabbits; Simvastatin

2005
Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry.
    Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4

    Topics: Apoptosis; Atorvastatin; Avidin; Biotin; Cell Line; Cell Separation; Cells, Cultured; Drug Industry; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia; Microscopy, Fluorescence; Necrosis; Pharmaceutical Preparations; Pravastatin; Propidium; Pyridines; Pyrroles; Simvastatin; Time Factors

2005
Induction of micronuclei in CHO cells by bleomycin but not by X-irradiation is decreased by treatment with HMG-CoA reductase inhibitors.
    Journal of radiation research, 2005, Volume: 46, Issue:2

    Topics: Animals; Bleomycin; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Micronuclei, Chromosome-Defective; Pravastatin; Radiation Dosage; Radiation Tolerance; X-Rays

2005
The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells.
    The Journal of surgical research, 2005, Volume: 129, Issue:1

    Topics: Atorvastatin; Cell Division; Cell Movement; Chemotaxis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Myocytes, Smooth Muscle; Pravastatin; Pyridines; Pyrroles; Saphenous Vein; Simvastatin

2005
Not all statins interfere with clopidogrel during antiplatelet therapy.
    European journal of clinical investigation, 2005, Volume: 35, Issue:8

    Topics: Adult; Atorvastatin; Chromatography, High Pressure Liquid; Clopidogrel; Drug Interactions; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Ticlopidine

2005
Binding thermodynamics of statins to HMG-CoA reductase.
    Biochemistry, 2005, Sep-06, Volume: 44, Issue:35

    Topics: Atorvastatin; Binding Sites; Calorimetry; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Protein Binding; Pyridines; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Thermodynamics

2005
Differences between statins on clinical endpoints: a population-based cohort study.
    Current medical research and opinion, 2005, Volume: 21, Issue:9

    Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Cholesterol; Cohort Studies; Endpoint Determination; Family Practice; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Netherlands; Pravastatin; Pyridines; Pyrroles; Simvastatin; Treatment Outcome

2005
Differential associations of statin and fibrate treatment with carotid arterial remodeling.
    American journal of hypertension, 2005, Volume: 18, Issue:11

    Topics: Adult; Atorvastatin; Bezafibrate; Body Mass Index; Carotid Arteries; Cholesterol, HDL; Clofibric Acid; Cohort Studies; Dyslipidemias; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fibric Acids; Fluvastatin; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Male; Middle Aged; Multivariate Analysis; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography

2005
The long-term course of low-density lipoprotein cholesterol after initiation of statin treatment: retrospective database analysis over 3 years in health maintenance organization enrollees.
    Clinical therapeutics, 2005, Volume: 27, Issue:10

    Topics: Aged; Anticholesteremic Agents; Cholesterol, LDL; Data Interpretation, Statistical; Fatty Acids, Monounsaturated; Female; Fluvastatin; Health Maintenance Organizations; Humans; Hyperlipidemias; Indoles; Long-Term Care; Male; Middle Aged; Pravastatin; Retrospective Studies; Time Factors

2005
Use of hydroxy-methyl-glutaryl coenzyme A reductase inhibitors is associated with risk of lymphoid malignancies.
    Cancer science, 2006, Volume: 97, Issue:2

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Japan; Lymphoma; Male; Multiple Myeloma; Pravastatin; Risk Factors; Simvastatin

2006
Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro.
    Biochemical pharmacology, 2006, Apr-28, Volume: 71, Issue:9

    Topics: Adult; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Cells, Cultured; DNA Fragmentation; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Histones; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Myeloid Cell Leukemia Sequence 1 Protein; Myocytes, Cardiac; Neoplasm Proteins; Pravastatin; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA, Messenger; Simvastatin

2006
Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction.
    Journal of the American Geriatrics Society, 2006, Volume: 54, Issue:3

    Topics: Age Factors; Aged, 80 and over; Atorvastatin; Cholesterol, LDL; Drug Prescriptions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Myocardial Infarction; Odds Ratio; Pravastatin; Pyridines; Pyrroles; Retrospective Studies; Survival Rate; Treatment Outcome

2006
Cost-effectiveness analysis of cholesterol-lowering therapies in Spain.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2006, Volume: 6, Issue:3

    Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Cholestyramine Resin; Clinical Trials as Topic; Coronary Disease; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Meta-Analysis as Topic; Pravastatin; Pyrroles; Risk Factors; Simvastatin; Spain

2006
Management of cardiovascular risk in patients receiving calcineurin inhibitors--a case report.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21 Suppl 3

    Topics: Acenocoumarol; Amiodarone; Angioplasty; Calcineurin Inhibitors; Carbazoles; Carvedilol; Cyclosporine; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Immunosuppressive Agents; Indoles; Kidney Transplantation; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Postoperative Complications; Pravastatin; Prednisone; Propanolamines; Risk Factors; Tacrolimus; Treatment Outcome

2006
Persistence and adherence to cholesterol lowering agents: evidence from Régie de l'Assurance Maladie du Québec data.
    American heart journal, 2006, Volume: 152, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Coronary Disease; Databases, Factual; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Middle Aged; Patient Compliance; Pravastatin; Pyrroles; Quebec; Registries; Retrospective Studies; Simvastatin

2006
Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer.
    Urologic nursing, 2006, Volume: 26, Issue:4

    Topics: Aged; Atorvastatin; Biopsy; Brachytherapy; Cause of Death; Chemotherapy, Adjuvant; Chi-Square Distribution; Disease-Free Survival; Fatty Acids, Monounsaturated; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Neoplasm Staging; Pravastatin; Proportional Hazards Models; Prostatic Neoplasms; Pyrroles; Retrospective Studies; Simvastatin; Survival Analysis

2006
Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:9

    Topics: Cell Cycle; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Fatty Acids, Monounsaturated; Fluvastatin; G1 Phase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; p21-Activated Kinases; Phosphorylation; Pravastatin; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Simvastatin

2006
Toxicity of statins on rat skeletal muscle mitochondria.
    Cellular and molecular life sciences : CMLS, 2006, Volume: 63, Issue:19-20

    Topics: Animals; Apoptosis; Atorvastatin; Cytochromes c; DNA Fragmentation; Fatty Acids; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potentials; Mitochondria, Muscle; Mitochondrial Membranes; Muscle, Skeletal; Oxygen; Pravastatin; Pyridines; Pyrroles; Rats; Simvastatin

2006
Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis.
    International immunology, 2007, Volume: 19, Issue:2

    Topics: Cell Line; Cytoplasmic Granules; Cytotoxicity, Immunologic; Enzyme-Linked Immunosorbent Assay; Exocytosis; Fatty Acids, Monounsaturated; Fluvastatin; Granzymes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Killer Cells, Natural; Lysosomal-Associated Membrane Protein 1; Mevalonic Acid; Pravastatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin

2007
Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells.
    European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3

    Topics: Androstadienes; Apoptosis; Axl Receptor Tyrosine Kinase; bcl-Associated Death Protein; Calcinosis; Caspase 3; Cells, Cultured; Enzyme Activation; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oncogene Proteins; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pravastatin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptor Protein-Tyrosine Kinases; Signal Transduction; Wortmannin

2007
Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats.
    Journal of pharmacological sciences, 2007, Volume: 103, Issue:3

    Topics: Administration, Oral; Anesthesia; Animals; Arrhythmias, Cardiac; Coronary Vessels; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl CoA Reductases; Indoles; Ischemia; Male; Peroxidase; Pravastatin; Rats; Rats, Sprague-Dawley

2007
Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8

    Topics: Animals; Anticholesteremic Agents; Biological Transport; Cell Line; CHO Cells; Chromans; Cricetinae; Cricetulus; Drug Interactions; Estrone; Fatty Acids, Monounsaturated; Fluvastatin; Gemfibrozil; Hepatocytes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Indoles; Kinetics; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Pravastatin; Protein Binding; Recombinant Proteins; Simvastatin; Solute Carrier Organic Anion Transporter Family Member 1B3; Taurocholic Acid; Thiazolidinediones; Troglitazone

2007
Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction.
    Clinical immunology (Orlando, Fla.), 2007, Volume: 123, Issue:3

    Topics: Calcineurin Inhibitors; CD40 Antigens; Cell Proliferation; Cyclosporine; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indoles; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-12; Interleukin-18; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mevalonic Acid; Monocytes; Naphthalenes; Oxazines; Pravastatin; T-Lymphocytes; Tacrolimus

2007
Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line.
    Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:5

    Topics: Analysis of Variance; Aryl Hydrocarbon Hydroxylases; Atorvastatin; Blotting, Western; Cell Line; Cell Proliferation; Cell Survival; Constitutive Androstane Receptor; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Pregnane X Receptor; Pyrroles; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saphenous Vein; Transcription Factors; Up-Regulation

2007
Effect of statin withdrawal on frequency of cardiac events after vascular surgery.
    The American journal of cardiology, 2007, Jul-15, Volume: 100, Issue:2

    Topics: Aged; Atorvastatin; Electrocardiography; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heart Diseases; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Myocardial Infarction; Postoperative Complications; Pravastatin; Pyrroles; Simvastatin; Substance Withdrawal Syndrome; Troponin T; Vascular Surgical Procedures

2007
Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:14

    Topics: Animals; Cell Line; Cells, Cultured; Enzyme Activation; Fatty Acids, Monounsaturated; Female; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Muscle Fibers, Skeletal; Muscle, Skeletal; Pravastatin; rab GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Rats, Wistar; Vacuoles

2007
HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells.
    Journal of vascular research, 2007, Volume: 44, Issue:6

    Topics: Atherosclerosis; Cell Adhesion; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Endothelial Cells; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Leukocytes; Lovastatin; NF-kappa B; Nicotine; Nicotinic Agonists; Pravastatin; Protein Kinase C; Reactive Oxygen Species; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Simvastatin; Smoking; Superoxide Dismutase; Time Factors; Vascular Cell Adhesion Molecule-1

2007
Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study.
    Biomedical chromatography : BMC, 2008, Volume: 22, Issue:2

    Topics: Chromatography, Liquid; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Quinolines; Tandem Mass Spectrometry

2008
Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.
    The American journal of geriatric pharmacotherapy, 2007, Volume: 5, Issue:3

    Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Cohort Studies; Coronary Disease; Databases, Factual; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Managed Care Programs; Odds Ratio; Pravastatin; Pyrimidines; Pyrroles; Retrospective Studies; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Treatment Outcome

2007
Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:4

    Topics: Atorvastatin; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pravastatin; Pyrroles; Saphenous Vein; Simvastatin

2007
Regulation of the PTEN promoter by statins and SREBP.
    Human molecular genetics, 2008, Apr-01, Volume: 17, Issue:7

    Topics: Cell Line; Electrophoretic Mobility Shift Assay; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Genes, Reporter; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; PPAR gamma; Pravastatin; Promoter Regions, Genetic; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Simvastatin; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation

2008
Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Apr-23, Volume: 33, Issue:4-5

    Topics: Acids; Atorvastatin; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Stability; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Indoles; Lactones; Microscopy, Fluorescence; Molecular Structure; Muscle Fibers, Skeletal; Muscle, Skeletal; Pravastatin; Pyrroles; Satellite Cells, Skeletal Muscle; Simvastatin; Structure-Activity Relationship

2008
Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.
    Pharmacogenetics and genomics, 2008, Volume: 18, Issue:4

    Topics: Anticholesteremic Agents; Apolipoproteins E; Cholesterol, LDL; Cohort Studies; Diabetes Mellitus, Type 2; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Longitudinal Studies; Male; Middle Aged; Pravastatin; Pyridines; Retrospective Studies; Scotland; Simvastatin; Treatment Outcome

2008
Lipid levels and low-density lipoprotein cholesterol goal attainment in diabetic patients: rosuvastatin compared with other statins in usual care.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:5

    Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Cholesterol, LDL; Cohort Studies; Diabetes Complications; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Managed Care Programs; Middle Aged; Practice Guidelines as Topic; Pravastatin; Pyrimidines; Pyrroles; Retrospective Studies; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Treatment Outcome; United States

2008
Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:2

    Topics: Adult; Aged; Alleles; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Decision Making; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genotype; Germany; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Inpatients; Linear Models; Lovastatin; Male; Middle Aged; Multivariate Analysis; Pravastatin; Predictive Value of Tests; Pyridines; Pyrroles; Simvastatin; Triglycerides

2008
Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.
    British journal of pharmacology, 2008, Volume: 154, Issue:7

    Topics: Animals; Cell Death; Cell Line; Fatty Acids, Monounsaturated; Female; Fibroblasts; Fluvastatin; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts; Organic Anion Transporters; Pravastatin; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Satellite Cells, Skeletal Muscle

2008
Statins alone are ineffective in cerebral malaria but potentiate artesunate.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atorvastatin; Disease Models, Animal; Drug Synergism; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Malaria, Cerebral; Malaria, Falciparum; Mice; Neuroprotective Agents; Pravastatin; Pyrroles; Simvastatin

2008
The influence of statin medications on prostate-specific antigen levels.
    Journal of the National Cancer Institute, 2008, Nov-05, Volume: 100, Issue:21

    Topics: Aged; Atorvastatin; Biomarkers, Tumor; Cholesterol, HDL; Cholesterol, LDL; Early Diagnosis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Linear Models; Longitudinal Studies; Lovastatin; Male; Middle Aged; Multivariate Analysis; Pravastatin; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrroles; Risk Assessment; Simvastatin; Veterans

2008
Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.
    Journal of pharmacological sciences, 2009, Volume: 109, Issue:1

    Topics: Amides; Androstadienes; Animals; Caspase 3; Cell Culture Techniques; Cell Survival; Creatine Kinase; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fibroblasts; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Infusions, Intravenous; L Cells; Mice; Muscle, Skeletal; Pravastatin; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Subcellular Fractions; Time Factors; Wortmannin

2009
[Statin therapy and muscle disorders].
    Orvosi hetilap, 2009, Feb-08, Volume: 150, Issue:6

    Topics: Atorvastatin; Biological Availability; Cytochrome P-450 Enzyme System; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Muscle, Skeletal; Muscular Diseases; Pravastatin; Pyrimidines; Pyrroles; Rhabdomyolysis; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2009
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:12

    Topics: Antibodies, Monoclonal; Apoptosis; Cell Adhesion; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Eosinophils; Fatty Acids, Monounsaturated; Fluvastatin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Intercellular Adhesion Molecule-1; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Microfluidic Analytical Techniques; Microfluidics; Pravastatin; Recombinant Proteins; Simvastatin; Vascular Cell Adhesion Molecule-1

2009
No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.
    British journal of clinical pharmacology, 2009, Volume: 68, Issue:2

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Genotype; Haplotypes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Polymorphism, Single Nucleotide; Pravastatin; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Young Adult

2009
In-vitro release kinetics and stability of anticardiovascular drugs-intercalated layered double hydroxide nanohybrids.
    The journal of physical chemistry. B, 2009, Nov-12, Volume: 113, Issue:45

    Topics: Anticholesteremic Agents; Chemical Precipitation; Delayed-Action Preparations; Diffusion; Drug Carriers; Drug Stability; Fatty Acids, Monounsaturated; Fluvastatin; Hydrophobic and Hydrophilic Interactions; Indoles; Kinetics; Nanostructures; Pravastatin; Static Electricity

2009
Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.
    Pharmacogenomics, 2009, Volume: 10, Issue:10

    Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cross-Over Studies; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genetic Variation; Genotype; Half-Life; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Metabolic Clearance Rate; Neoplasm Proteins; Polymorphism, Single Nucleotide; Pravastatin; Simvastatin

2009
Low-dosage statins reduce choroidal damage in hypercholesterolemic rabbits.
    Acta ophthalmologica, 2011, Volume: 89, Issue:7

    Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Choroid; Choroid Diseases; Disease Models, Animal; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Male; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Triglycerides

2011
[Pharmaco-economic optimization of cholesterol-lowering treatment with statins].
    Medicina clinica, 2011, Jun-25, Volume: 137, Issue:3

    Topics: Atorvastatin; Cholesterol, LDL; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Goals; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Practice Guidelines as Topic; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Spain; Sulfonamides

2011
The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals.
    European journal of pharmacology, 2011, Jan-25, Volume: 651, Issue:1-3

    Topics: Animals; Arteries; Body Weight; Estrogen Replacement Therapy; Fatty Acids, Monounsaturated; Female; Fluvastatin; Hot Flashes; Indoles; Menopause; Mice; Nitric Oxide; Organ Size; Ovariectomy; Physical Conditioning, Animal; Pravastatin; Rats; Skin; Uterus; Vasoconstriction; Vasodilation; Vasomotor System

2011
A novel use of oxidative coupling reactions for determination of some statins (cholesterol-lowering drugs) in pharmaceutical formulations.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2011, Volume: 78, Issue:3

    Topics: Atorvastatin; Chemistry, Pharmaceutical; Dosage Forms; Excipients; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Molecular Structure; Oxidation-Reduction; Oxidative Coupling; Pravastatin; Pyrroles; Spectrophotometry

2011
Statins and prostate cancer diagnosis and grade in a veterans population.
    Journal of the National Cancer Institute, 2011, Jun-08, Volume: 103, Issue:11

    Topics: Aged; Aged, 80 and over; Anticarcinogenic Agents; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Biomarkers, Tumor; Cholesterol; Confounding Factors, Epidemiologic; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Lipids; Lovastatin; Male; Middle Aged; Multivariate Analysis; New England; Pravastatin; Proportional Hazards Models; Prostatic Neoplasms; Pyrroles; Risk Assessment; Severity of Illness Index; Simvastatin; Veterans

2011
EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin.
    Molecular and cellular biochemistry, 2012, Volume: 364, Issue:1-2

    Topics: DNA Breaks; Electron Spin Resonance Spectroscopy; Fatty Acids, Monounsaturated; Ferrous Compounds; Fluvastatin; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Plasmids; Pravastatin; Reactive Oxygen Species; Spin Trapping

2012
Selected statins produce rapid spinal motor neuron loss in vitro.
    BMC musculoskeletal disorders, 2012, Jun-15, Volume: 13

    Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Indoles; Motor Neurons; Neurites; Pravastatin; Rats; Schwann Cells; Simvastatin; Spinal Nerves; Time Factors; Tissue Culture Techniques

2012
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Atorvastatin; Cell Compartmentation; Chemokine CXCL1; Chemokines; E-Selectin; Endocytosis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-1beta; Intracellular Space; Multivesicular Bodies; Pravastatin; Prenylation; Pyrroles; Simvastatin; Solubility; Subcellular Fractions; Tetraspanin 30

2012
A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Atorvastatin; Databases, Factual; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Muscle, Skeletal; Pravastatin; Pyrimidines; Pyrroles; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Tendons; United States; United States Food and Drug Administration

2012
Multilevel analysis of the influence of patients' and general practitioners' characteristics on patented versus multiple-sourced statin prescribing in France.
    Applied health economics and health policy, 2013, Volume: 11, Issue:3

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Atorvastatin; Diabetes Mellitus; Drug Prescriptions; Drugs, Generic; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; France; General Practitioners; Heart Diseases; Heptanoic Acids; Humans; Indoles; Lipid Metabolism Disorders; Male; Middle Aged; Models, Statistical; Practice Patterns, Physicians'; Pravastatin; Prescription Drugs; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2013
Long-term use of statins reduces the risk of hospitalization for dementia.
    Atherosclerosis, 2013, Volume: 230, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Case-Control Studies; Dementia; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Italy; Logistic Models; Male; Middle Aged; Pravastatin; Pyrroles; Risk; Simvastatin; Time Factors

2013
Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:6

    Topics: Animals; Atorvastatin; ATP-Binding Cassette Transporters; Bilirubin; Biological Transport; Cell Culture Techniques; Cells, Cultured; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Pravastatin; Pyrimidines; Pyrroles; Rats; Rosuvastatin Calcium; Sulfonamides

2014
Statins upregulate cystathionine γ-lyase transcription and H2S generation via activating Akt signaling in macrophage.
    Pharmacological research, 2014, Volume: 87

    Topics: Animals; Atorvastatin; Cell Line; Cystathionine gamma-Lyase; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydrogen Sulfide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Macrophages; Mice; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; RNA, Messenger; Signal Transduction; Up-Regulation

2014
Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort.
    Pharmacogenetics and genomics, 2015, Volume: 25, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Pharmacological; Coronary Disease; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genetic Association Studies; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Metabolism; Liver-Specific Organic Anion Transporter 1; Lovastatin; Male; Middle Aged; Organic Anion Transporters; Pravastatin; Risk Assessment; Simvastatin

2015
Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2015, Feb-17, Volume: 187, Issue:3

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Clarithromycin; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperkalemia; Indoles; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Pravastatin; Pyrimidines; Retrospective Studies; Rhabdomyolysis; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides

2015
Green analytical method development for statin analysis.
    Journal of chromatography. A, 2015, Feb-06, Volume: 1380

    Topics: Acetonitriles; Atorvastatin; Chromatography, High Pressure Liquid; Ethanol; Fatty Acids, Monounsaturated; Fluvastatin; Green Chemistry Technology; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Pyrroles; Solubility; Solvents

2015
Comparative evaluation of HMG CoA reductase inhibitors in experimentally-induced myocardial necrosis: Biochemical, morphological and histological studies.
    European journal of pharmacology, 2015, Oct-05, Volume: 764

    Topics: Adenosine Triphosphatases; Animals; Atorvastatin; Blood Glucose; Cardiotonic Agents; Catalase; Cholesterol; Fatty Acids, Monounsaturated; Fluvastatin; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoproterenol; Male; Myocardial Infarction; Myocardium; Necrosis; Pravastatin; Rats, Wistar; Rosuvastatin Calcium; Simvastatin; Superoxide Dismutase; Triglycerides

2015
Neuroprotective Effects of Low-Dose Statins in the Retinal Ultrastructure of Hypercholesterolemic Rabbits.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Animals; Cholesterol; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Glial Fibrillary Acidic Protein; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Male; Neuroprotective Agents; Pravastatin; Rabbits; Retina; Retinal Vessels

2016
Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.
    Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:5

    Topics: Antibiotics, Antitubercular; Computer Simulation; Cyclosporine; Drug Interactions; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Models, Biological; Organic Anion Transporters; Pravastatin; Quinolines; Rifampin

2016
Trends in Statin Use in Seniors 1999 to 2013: Time Series Analysis.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Aged; Aged, 80 and over; Atorvastatin; Clinical Trials as Topic; Fatty Acids, Monounsaturated; Female; Fluvastatin; Health Knowledge, Attitudes, Practice; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Interrupted Time Series Analysis; Lovastatin; Male; Nova Scotia; Pravastatin; Prescription Drugs; Retrospective Studies; Rosuvastatin Calcium; Simvastatin

2016
Characterization of interactions of simvastatin, pravastatin, fluvastatin, and pitavastatin with bovine serum albumin: multiple spectroscopic and molecular docking.
    Journal of biomolecular structure & dynamics, 2017, Volume: 35, Issue:7

    Topics: Animals; Binding Sites; Cattle; Fatty Acids, Monounsaturated; Fluvastatin; Hydrogen Bonding; Indoles; Kinetics; Molecular Docking Simulation; Pravastatin; Protein Binding; Quinolines; Serum Albumin, Bovine; Simvastatin; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thermodynamics

2017
Interaction of different statins with model membranes by NMR data.
    Biochimica et biophysica acta. Biomembranes, 2017, Volume: 1859, Issue:3

    Topics: Deuterium Oxide; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Magnetic Resonance Spectroscopy; Micelles; Phosphorylcholine; Pravastatin; Simvastatin

2017
Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-Like Cells.
    Mediators of inflammation, 2017, Volume: 2017

    Topics: Anti-Inflammatory Agents; Antioxidants; Atorvastatin; Cell Proliferation; Chronic Disease; Dinoprostone; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Inflammation; Interleukin-1beta; Lipids; Lipopolysaccharides; Microglia; Monocytes; Nitric Oxide; Pravastatin; Quinolines; Reactive Oxygen Species; Rosuvastatin Calcium; Simvastatin; THP-1 Cells; Tumor Necrosis Factor-alpha

2017
Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures.
    Acta pharmaceutica (Zagreb, Croatia), 2017, Dec-20, Volume: 67, Issue:4

    Topics: Atorvastatin; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry; Valsartan

2017
Cardioprotective cytokine interleukin-33 is up-regulated by statins in human cardiac tissue.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:12

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cyclohexenes; Cytokines; Diphosphonates; Fibroblasts; Fluvastatin; Gene Expression Regulation; Heart; Heart Diseases; Humans; Interleukin-33; Lovastatin; Mevalonic Acid; Monoterpenes; Myocardium; Myocytes, Cardiac; Pravastatin; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Thiazolidines

2018
Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy.
    Biochimica et biophysica acta. Biomembranes, 2019, 03-01, Volume: 1861, Issue:3

    Topics: Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Bilayers; Lovastatin; Magnetic Resonance Spectroscopy; Phosphatidylcholines; Phospholipids; Pravastatin; Simvastatin

2019
PRavastatin Versus FlUVastatin After Statin Intolerance: The PRUV-Intolerance Study With Propensity Score Matching.
    The American journal of medicine, 2019, Volume: 132, Issue:11

    Topics: Aged; Biomarkers; Creatine Kinase; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Kidney Failure, Chronic; Male; Middle Aged; Pravastatin; Propensity Score; Retrospective Studies; Risk Factors

2019
Resveratrol for protection against statin toxicity in C2C12 and H9c2 cells.
    Journal of biochemical and molecular toxicology, 2020, Volume: 34, Issue:6

    Topics: Animals; Atorvastatin; Caspase 3; Caspase 7; Cell Line; Cell Survival; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Myoblasts; Pravastatin; Protective Agents; Rats; Resveratrol; Signal Transduction; Simvastatin

2020
Comparison of the Effects of Statins on A549 Nonsmall-Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out.
    Lipids, 2021, Volume: 56, Issue:3

    Topics: A549 Cells; Atorvastatin; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Lung Neoplasms; Pravastatin; Rosuvastatin Calcium; Simvastatin; Spectroscopy, Fourier Transform Infrared

2021
Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic Studies.
    International journal of molecular sciences, 2021, May-24, Volume: 22, Issue:11

    Topics: Adenylate Kinase; Amino Acid Sequence; Atorvastatin; Circular Dichroism; Fluvastatin; Geobacillus stearothermophilus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Isoenzymes; Kinetics; Ligands; Molecular Docking Simulation; Pravastatin; Protein Binding; Recombinant Proteins; Rosuvastatin Calcium; Sequence Alignment; Simvastatin; Spectrometry, Fluorescence; Spectrophotometry; Static Electricity; Temperature

2021
Adverse drug reactions of statin therapy in China from 1989 to 2019: a national database analysis.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:e1

    Topics: Drug-Related Side Effects and Adverse Reactions; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Rosuvastatin Calcium; Simvastatin

2023
Long-term outcomes of statin dose, class, and use intensity on primary prevention of cardiovascular mortality: a national T2DM cohort study.
    European journal of clinical pharmacology, 2023, Volume: 79, Issue:5

    Topics: Atorvastatin; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Primary Prevention; Rosuvastatin Calcium; Simvastatin

2023
Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2 , and CYP2C9 variants.
    Pharmacogenetics and genomics, 2023, 09-01, Volume: 33, Issue:7

    Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cytochrome P-450 CYP2C9; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Neoplasm Proteins; Pharmacogenetics; Pravastatin; Rosuvastatin Calcium; Simvastatin

2023